Fan, Ruyan, Wei, Wensong ORCID: 0000-0001-5214-2973 , Wei, Youjing, Lin, Xue, Zhou, Shaobo ORCID: 0000-0001-5214-2973 and Wang, Lu (2024) Phenolics-rich extracts from Agarwood leaf-tea alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis via modulating intestinal barrier function and gut microbiota. Molecular Nutrition and Food Research. ISSN 1613-4125 (Print), 1613-4133 (Online) (In Press)

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Abstract

The increasing incidence of ulcerative colitis (UC) and the side effects of its therapeutic drugs have spurred the search for functional components derived from natural products as alternative treatments. This study investigated the effects of phenolics-rich extracts from Agarwood leaf tea (ALP) on alleviating dextran sulfate sodium (DSS)-induced colitis and explored its potential mechanisms. Results showed that ALP supplementation improved typical UC symptoms, reduced pro-inflammatory cytokines, and enhanced intestinal barrier function by promoting the expression of tight junction proteins Occludin and ZO-1 in colonic tissues. This repair of the intestinal barrier helped mitigate further tissue damage. Additionally, ALP effectively inhibited the NF-κB signaling pathway, leading to a decrease in pro-inflammatory cytokine release. ALP also modulated the gut microbiota in colitic mice, increasing beneficial bacteria (e.g., Parabacteroides, Chlamydia, Lachnospiraceae) and reducing harmful bacteria (e.g., Bactero

Item Type:	Article
Uncontrolled Keywords:	Agarwood leaf; ulcerative colitis; intestinal barrier; gut microbiota; NF-κB signaling pathway
Subjects:	Q Science > Q Science (General) Q Science > QK Botany R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	15 Nov 2024 12:51
URI:	http://gala.gre.ac.uk/id/eprint/48620

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