Fan, Ruyan, Wei, Wensong ORCID: https://orcid.org/0000-0001-5214-2973, Wei, Youjing, Lin, Xue, Zhou, Shaobo ORCID: https://orcid.org/0000-0001-5214-2973 and Wang, Lu (2024) Phenolics-rich extracts from Agarwood leaf-tea alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis via modulating intestinal barrier function and gut microbiota. Molecular Nutrition and Food Research. ISSN 1613-4125 (Print), 1613-4133 (Online) (doi:10.1002/mnfr.202400566)

PDF (Author's Accepted Manuscript) 48620 ZHOU_Phenolics-Rich_Extracts_From_Agarwood_Leaf-Tea_Alleviate_Dextran_Sulfate_Sodium_DSS-Induced_Ulcerative_Colitis_(AAM)_2024.pdf - Accepted Version Restricted to Repository staff only until 21 November 2025. Download (2MB) | Request a copy

Abstract

Scope
At present, the incidence rate of ulcerative colitis (UC) continues to increase, causing a global burden. In addition, therapeutic drugs have great side effects. According to modern pharmacology, agarwood leaves have anti-inflammatory, antibacterial, hypoglycemic, and lipid-lowering effects. Therefore, this experiment on DSS induced colitis treatment of polyphenolic substances in agarwood leaves is feasible and in line with the current hot topic of using natural substances instead of drugs for treatment.

Methods and results
ALP supplementation promotes the expression of tight junction proteins occludin and Zonula occludens protein 1 (ZO-1) on colonic tissues, repairs the intestinal barrier, and relieves further colonic tissue damage. Besides, ALP effectively inhibits the activation of nuclear factor kappa-B (NF-кB) signaling pathway and reduces the release of proinflammatory cytokines. Moreover, ALP reverses the alteration of gut microbiota in the colitic mice by increasing the abundances of Parabacteroides, Chlamydia, and Lachnospiraceae, and decreasing the abundances of Bacteroides and Phocaeicola. Furthermore, the correlation analysis suggested that ALP can attenuate DSS-induced UC, which is probably related to the alterations in the gut microbiota.

Conclusion
ALP can ameliorate DSS-induced UC by modulating gut microbiota, intestinal barrier function, and inflammatory responses.

Item Type:	Article
Uncontrolled Keywords:	Agarwood leaf, ulcerative colitis, intestinal barrier, gut microbiota, NF-κB signaling pathway
Subjects:	Q Science > Q Science (General) Q Science > QK Botany R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	09 Dec 2024 13:41
URI:	http://gala.gre.ac.uk/id/eprint/48620

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