Mccrone, Paul ORCID: 0000-0001-7001-4502 , Patel, Meenal, Hotopf, Matthew, Moss-Morris, Rona, Ashworth, Mark, David, Anthony S, Husain, Mujtaba, James, Kirsty, Landau, Sabine and Chalder, Trudie (2024) Cost-utility analysis of transdiagnostic cognitive behavioural therapy for people with persistent physical symptoms in contact with specialist services evaluated in the PRINCE secondary trial. Psychosomatic Medicine: Journal of Biobehavioral Medicine. ISSN 0033-3174 (Print), 1534-7796 (Online) (In Press)

PDF (AAM) 48303 McCRONE_Cost-utility_Analysis_of_Transdiagnostic_Cognitive_Behavioural_Therapy_for_People_with_Persistent_Physical_Symptoms_in_Contact_with_Specialist_Services_Evaluated_in_the_PRINCE_Secondary_Trial_(AAM)_2024.pdf - Accepted Version Restricted to Repository staff only Download (402kB) | Request a copy

Abstract

Objective: To compare the cost-utility of transdiagnostic cognitive behavioural therapy (TDT-CBT) plus standardised medical care (SMC) to SMC alone to support people with persistent physical symptoms in contact with specialist services.
Methods: This study compared the cost-utility of TDT-CBT. A two-arm randomised controlled trial was conducted in secondary care settings. Participants received either TDT-CBT+SMC or SMC alone. Measures were taken at baseline and at 9-, 20-, 40-, and 52-week follow-up. Service use was measured, and costs calculated. Costs were combined with quality-adjusted life years (QALYs) based on the EQ-5D-5L using incremental cost-utility ratios with uncertainty addressed using cost-effectiveness planes and acceptability curves.
Results: The costs during the follow-up period were £3473 for TDT-CBT+SMC and £3104 for SMC alone. The incremental cost for TDT-CBT+SMC adjusting for baseline was £482 (95% CI, -£399 to £1233). QALYs over the follow-up were 0.578 for TDT-CBT+SMC and 0.542 for SMC alone. The incremental QALY was 0.038 (95% CI, -0.005 to 0.080). The incremental cost per QALY was £12,684 for TDT-CBT+SMC. There was a 68.3% likelihood that TDT-CBT+SMC was the most cost-effective option at a threshold of £20,000 per QALY.
Conclusion: Adding TDT-CTB to SMC results in slightly increased costs and slightly better outcomes in terms of QALYs. This represents a cost-effective option based on the conventional QALY threshold value.

Item Type:	Article
Uncontrolled Keywords:	cost-utility, economic evaluation, cognitive behavioural therapy, persistent physical symptoms
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Mental Health Faculty of Education, Health & Human Sciences > School of Health Sciences (HEA)
Last Modified:	16 Oct 2024 10:28
URI:	http://gala.gre.ac.uk/id/eprint/48303

Actions (login required)

View Item

Downloads