Laza-Cagigas, Roberto, Larumbe-Zabala, Eneko, Rampal, Tara, Seijo Bujia, Marcos ORCID: 0000-0003-1637-6670 and Naclerio, Fernando ORCID: 0000-0001-7405-4894 (2024) Effect of prehabilitation programmes on functional capacity in patients awaiting oncological resections: a systematic review and meta-analysis of randomised controlled trials. Supportive Care in Cancer. ISSN 0941-4355 (Print), 1433-7339 (Online) (In Press)

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Abstract

Purpose: To investigate the effects of prehabilitation on the perioperative functional capacity of patients awaiting oncological resections.
Methods: A systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and within the databases Cochrane Library, EBSCOhost, Google Scholar, MEDLINE PubMed, and Web of Science. The eligibility criteria were set to include peer-reviewed randomised control trials including only adult (≥18 years old) patients undergoing any type of prehabilitation (PREHAB) prior to any type of oncological resection. The studies had to feature at least one control group undergoing standard care (SC) and had to assess functional capacity by means of a 6-minute walk distance (6MWD) or peak oxygen uptake (VO2Peak) at different stages pre- and post- operatively.
Results Twenty-seven randomised controlled trials involving 1994 patients were included. After processing the data, the number of patients was 1889. Studies featured different cancer specialties: lung (11), colorectal (5), urological (4), abdominal (3), esophagogastric (2), liver (1), and gastrointestinal (1). Overall, PREHAB enhanced both 6MWD (g = 0.273, 95% CI 0.174 to 0.371, Z = 5.406, p < 0.001) and VO2Peak (g = 0.615, 95% CI 0.243 to 0.987, Z = 3.240, p = 0.001) compared with SC. The 6MWD subgroup analysis revealed a small mean effect size favouring both unimodal and multimodal PREHAB interventions.
Conclusion: These findings support that prehabilitation, whether implemented as unimodal or multimodal format, elicits small preoperative improvements in functional capacity in patients awaiting oncological resections.
PROSPERO registration number CRD42023428676

Item Type:	Article
Uncontrolled Keywords:	cancer; surgery; exercise
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM) Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development
Last Modified:	13 Sep 2024 11:19
URI:	http://gala.gre.ac.uk/id/eprint/47977

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