Sensini, Alberto ORCID: 0000-0003-0681-5887 , Stamati, Olga ORCID: 0000-0002-7492-2134 , Marchiori, Gregorio ORCID: 0000-0002-2171-1851 , Sancisi, Nicola ORCID: 0000-0003-3005-6489 , Gotti, Carlo, Giavaresi, Gianluca, Cristofolini, Luca ORCID: 0000-0002-7473-6868 , Focarete, Maria Letizia, Zucchelli, Andrea ORCID: 0000-0002-3466-2913 and Tozzi, Gianluca (2024) Full-field strain distribution in hierarchical electrospun nanofibrous poly-L(lactic) acid/collagen scaffolds for tendon and ligament regeneration: a multiscale study. Heliyon, 10 (5):e26796. pp. 1-15. ISSN 2405-8440 (Online) (doi:https://doi.org/10.1016/j.heliyon.2024.e26796)

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Abstract

Regeneration of injured tendons and ligaments (T/L) is a worldwide need. In this study electrospun hierarchical scaffolds made of a poly-L (lactic) acid/collagen blend were developed reproducing all the multiscale levels of aggregation of these tissues. Scanning electron microscopy, microCT and tensile mechanical tests were carried out, including a multiscale digital volume correlation analysis to measure the full-field strain distribution of electrospun structures. The principal strains (εp1 and εp3) described the pattern of strains caused by the nanofibers rearrangement, while the deviatoric strains (εD) revealed the related internal sliding of nanofibers and bundles. The results of this study confirmed the biomimicry of such electrospun hierarchical scaffolds, paving the way to further tissue engineering and clinical applications.

Item Type:	Article
Uncontrolled Keywords:	hierarchical scaffolds; electrospinning; MicroCT; in situ mechanical tests; digital volume correlation; tendons and ligaments
Subjects:	Q Science > Q Science (General) T Technology > T Technology (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Engineering (ENG)
Last Modified:	05 Mar 2024 14:07
URI:	http://gala.gre.ac.uk/id/eprint/46127

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