Spencer, John, Rathnam, Rajendra P. and Chowdhry, Babur Z. (2010) 1,4-Benzodiazipine-2-ones in medicinal chemistry. Future Medicinal Chemistry, 2 (9). pp. 1441-1449. ISSN 1756-8919 (doi:https://doi.org/10.4155/fmc.10.226)

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Abstract

1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to ‘classical’ CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.

Item Type:	Article
Uncontrolled Keywords:	G-protein coupled receptor antagonists, enzyme inhibitors, anticancer agents, palladacycle complexes, synthesis
Subjects:	Q Science > QD Chemistry R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI) Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Related URLs:	Publisher Publisher Organisation Organisation
Last Modified:	09 Oct 2021 04:46
URI:	http://gala.gre.ac.uk/id/eprint/4567

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