Kellet, S, Petrushkin, J, Ashworth, J, Connor, A, McLoone, E, Schmoll, C, Sharma, S, Agorogiannis, E, Williams, J, Choi, J, Injarie, A, Puvanachandra, N, Watts, P, Shafi, A, Millar, E, Long, V, Kumar, A, Hughes, E, Ritchie, A, Gonzalez-Martin, J, Pradeep, A, Anwar, S, Warrior, K, Muthusamy, B, Pilling, R, Benzimra, J, Reddy, A, Bush, K, Pharoah, D, Falzon,, K, O’Colmain, U, Knowles, R, Tadic, Valerija ORCID: https://orcid.org/0000-0003-3982-0340, Dick, A, Rahi, J and Solebo, A (2023) 2. Pathways to detection of non-infectious childhood uveitis in the UK: findings from the UNICORN cohort study. In: BMJ Ophthalmology Open. BMJ Publishing Group, A1-A1. ISSN 2044-6055 (doi:10.1136/bmjophth-2023-BIPOSA.2)

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Abstract

Introduction Prompt detection of childhood uveitis is key to minimising negative impact. From an internationally unique inception cohort, we report pathways to disease detection. UNICORNS is a national childhood non-infectious uveitis study with longitudinal collection of a standardised clinical dataset and patient reported outcomes. Descriptive analysis of baseline characteristics are reported. Amongst 150 recruited children (51% female, 31% non-white ethnicity) age at detection ranged from 2–18yrs (median 10). In 69%, uveitis was diagnosed following onset of symptoms: time from first symptoms to uveitis detection ranged from 0-739days (median 7days), with longer time to detection for those presenting initially to their general practitioner. Non symptomatic children were detected through JIA/other disease surveillance (16%), routine optometry review (5%) or child visual health screening (1%). Commonest underlying diagnoses at uveitis detection were JIA (17%), TINU (9%, higher than pre-pandemic reported UK disease frequency) and sarcoid (1%). 60% had no known systemic disease at uveitis detection. At disease detection, in at least one eye: 34% had structural complications (associated with greater time to detection – 17 days versus 4 days for uncomplicated presentation). The larger relative proportions of children with non-JIA uveitis reported here increase the importance of improving awareness of childhood uveitis amongst the wider clinical communities. There is scope for improvement of pathways to detection. Forthcoming analysis on the full cohort (251 recruited to date across 33 hospitals and 4 nations) will provide nationally representative data on management and the determinants of visual and broader developmental/well-being outcomes.

Item Type:	Conference Proceedings
Title of Proceedings:	BMJ Ophthalmology Open
Additional Information:	This is published conference proceedings abstract. Not sure how to specify accepted date apart from specifying the date when the paper was given: https://www.researchgate.net/publication/374479239_2_Pathways_to_detection_of_non-infectious_childhood_uveitis_in_the_UK_findings_from_the_UNICORN_cohort_study/fulltext/651ff897b0df2f20a2161eb1/2-Pathways-to-detection-of-non-infectious-childhood-uveitis-in-the-UK-findings-from-the-UNICORN-cohort-study.pdf?origin=publication_detail&_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uRG93bmxvYWQiLCJwcmV2aW91c1BhZ2UiOiJwdWJsaWNhdGlvbiJ9fQ
Uncontrolled Keywords:	uveitis
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	05 Jul 2024 13:30
URI:	http://gala.gre.ac.uk/id/eprint/44430

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