Kianfar, F., Chowdhry, B.Z., Boateng, J.S. ORCID: https://orcid.org/0000-0002-6310-729X and Antonijevic, M.D. ORCID: https://orcid.org/0000-0002-5847-7886 (2010) Investigation of the interaction between poloxamer 407 and poly (ethylene glycol) 600. Journal of Pharmacy and Pharmacology, 62 (10). pp. 1341-1342. ISSN 0022-3573 (Print), 2042-7158 (Online) (doi:10.1111/j.2042-7158.2010.01178.x)

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Abstract

The aim of this study was to evaluate the interactions between poly (ethylene glycol) (PEG) 600 and poloxamer 407 prior to their use in a pharmaceutical formulation.
Chemical interactions between various ingredients alter the stability of pharmaceutical product [1]. Investigating the interaction between starting materials is a pre-requisite to develop a stable high quality pharmaceutical formulation. Changes in melting point [2] directly influence the stability of a product. One of the fundamental changes that might modify the melting point of a compound and consequently alter the stability of the system is the interaction between excipient(s) and API(s). The formation of a mixture following the interaction between component compounds, influences the characteristics of the system which therefore need to be determined.

Item Type:	Article
Additional Information:	[1] Abstract published in Journal of Pharmacy and Pharmacology, Volume 62, Issue 10, October 2010 - Special Issue: UK-PharmSci 2010 - The Science of Medicines. Abstracts from the UK conference, 1-3 September 2010.
Uncontrolled Keywords:	PEG600, poloxamer 407, chemical interactions, differential scanning calorimetry
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI) Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Related URLs:	Publisher Organisation Organisation Organisation
Last Modified:	09 Oct 2021 04:46
URI:	http://gala.gre.ac.uk/id/eprint/4424

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