Pharmacophore and QSAR study of some novel selective COX-2 inhibitors as anti- cancer agents
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El-Mahrouky, Yomna 
ORCID: 0009-0005-2633-6164 and Nour, Mai S.
(2021)
Pharmacophore and QSAR study of some novel selective COX-2 inhibitors as anti- cancer agents.
In: OncoHub 2021. Connecting scientists for next generation cancer management, 15th Oct 2021, Virtual and Budapest, Romania.
(Unpublished)
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42711_EL MAHROUKY_ Pharmacophore_and_QSAR_study_of_some_novel_selective_COX_2_inhibitors_as_anti_cancer_agents.pdf - Presentation Download (170kB) | Preview |
Abstract
Cancer represents a global health concern worldwide owing to absence of an efficient therapy with appropriate safety profile. Therefore, recent research is devoted to develop more safe and efficient anticancer agents.
Cyclooxgenase-2 (COX-2) is a key enzyme in inducing an anti-cancer activity as it is involved in cancer survival, evasion of immunity, cancer cell repopulation during therapy and eventually reduces resistance to chemo- and radiotherapy. COX-2 enzyme is over expressed in variety of cancer cell types; thus treatment with selective COX-2 inhibitors could relieve symptoms and limit side effects. In this regard, design and synthesis of novel selective COX-2 inhibitors have always been of scientific attraction in treatment of cancerous cells. In the light of the above findings, this study was directed at studying the structure activity relationship analysis of some heterocyclic oxadiazoles compound via generating pharmcophore and QSAR models.
| Item Type: | Conference or Conference Paper (Poster) |
|---|---|
| Uncontrolled Keywords: | cancer; QSAR; cyclooxgenase-2; pharmcophore |
| Subjects: | Q Science > Q Science (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) T Technology > T Technology (General) |
| Faculty / School / Research Centre / Research Group: | Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI) |
| Related URLs: | |
| Last Modified: | 10 Jul 2023 09:01 |
| URI: | http://gala.gre.ac.uk/id/eprint/42711 |
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