Stromsky, Viktoria E., Hajkazemian, Melika ORCID: 0000-0003-1792-1829 , Vaisbourd, Elizabeth, Mozūraitis, Raimondas ORCID: 0000-0002-1719-2294 and Emami, S. Noushin ORCID: 0000-0001-7239-4457 (2021) Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources. Communications Biology, 4 (1):1161. pp. 1-10. ISSN 2399-3642 (doi:https://doi.org/10.1038/s42003-021-02689-8)

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Abstract

Recent data show that parasites manipulate the physiology of mosquitoes and human hosts to increase the probability of transmission. Here, we investigate phagostimulant activity of Plasmodium-metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), in the primary vectors of multiple human diseases, Anopheles coluzzii, An. arabiensis, An. gambiae s.s., Aedes aegypti, and Culex pipiens/Culex torrentium complex species. The addition of 10 µM HMBPP to blood meals significantly increased feeding in all the species investigated. Moreover, HMBPP also exhibited a phagostimulant property in plant-based-artificial-feeding-solution made of beetroot juice adjusted to neutral pH similar to that of blood. The addition of AlbuMAXTM as a lipid/protein source significantly improved the feeding rate of An. gambiae s.l. females providing optimised plant-based-artificial-feeding-solution for delivery toxins to control vector populations. Among natural and synthetic toxins tested, only fipronil sulfone did not reduce feeding. Overall, the toxic-plant-based-artificial-feeding-solution showed potential as an effector in environmentally friendly vector-control strategies.

Item Type:	Article
Uncontrolled Keywords:	malaria parasite; vector; disease transmission
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology Q Science > QL Zoology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Last Modified:	28 Apr 2023 08:19
URI:	http://gala.gre.ac.uk/id/eprint/42001

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