Ovsepian, Saak and Waxman, Stephen (2023) Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors. Nature Review Neuroscience, 12 (1):1. pp. 252-265. ISSN 1471-003X (Print), 1471-0048 (Online) (doi:10.1038/s41583-022-00673-7)

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Abstract

With sweeping advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology offers unprecedented selectivity for and control of a wide variety of biological processes, forging new opportunities for therapeutic interventions. This perspective summarizes state-of-the-art gene therapies enabled by recent innovations, with an emphasis on the expanding universe of molecular targets that govern the activity and function of primary sensory neurons and which might be exploited to effectively treat chronic pain.

Item Type:	Article
Uncontrolled Keywords:	chronic pain; nociception; sensory neurons; gene therapy
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH426 Genetics
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	20 Jul 2023 01:38
URI:	http://gala.gre.ac.uk/id/eprint/41638

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