Cornelius, Victoria J., Majcen, Natasa, Snowden, Martin J. ORCID: 0000-0002-1087-2692 , Mitchell, John C. ORCID: 0000-0003-2945-3292 and Voncina, Bojana (2006) Preparation of SMART wound dressings based on colloidal microgels and textile fibres. In: Smart Materials IV (Proceedings Volume). Proceedings of the Society of Photo-Optical Instrumentation Engineers (SPIE), 64130X (6413). Society of Photo-Optical Instrumentation Engineers (SPIE). ISBN 9780819465214 (doi:https://doi.org/10.1117/12.712573)

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Abstract

Wound dressings and other types of wound healing technologies are experiencing fast-paced development and rapid growth. As the population ages, demand will continue to rise for advanced dressings used to treat chronic wounds, such as pressure ulcers, venous stasis ulcers, and diabetic ulcers. Moist wound dressings, which facilitate natural wound healing in a cost-effective manner, will be increasingly important. In commercially available hydrogel / gauze wound dressings the gel swells to adsorb wound excreta and provide an efficient non adhesive particle barrier. An alternative to hydrogels are microgels. Essentially discrete colloidal gel particles, as a result of their very high surface area to volume ratio compared to bulk gels, they have a much faster response to external stimuli such as temperature or pH. In response to either an increase or decrease in solvent quality these porous networks shrink and swell reversibly. When swollen the interstitial regions within the polymer matrix are available for further chemistry; such as the incorporation of small molecules. The reversible shrinking and swelling as a function of external stimuli provides a novel drug release system. As the environmental conditions of a wound change over its lifetime, tending to increase in pH if there is an infection combining these discrete polymeric particles with a substrate such as cotton, results in a smart wound dressing.

Item Type:	Conference Proceedings
Title of Proceedings:	Smart Materials IV (Proceedings Volume)
Additional Information:	[1] First published online: 22nd December 2006. [2] SPIE is the The International Society for Optical Engineering. [3] This paper was presented at the SPIE International Symposium on Smart Materials, Nano-and Micro-Smart System, Adelaide University, Adelaide, AUSTRALIA, 11-13 December 2006. [4] SPIE Proceedings, Volume 6413.
Uncontrolled Keywords:	SMART wound dressings, matrices, molecules, networks, particles, polymers, veins, wound healing
Subjects:	R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation Organisation
Last Modified:	16 Apr 2020 13:26
URI:	http://gala.gre.ac.uk/id/eprint/4154

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