Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa
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Ayensu, Isaac, Mitchell, John
ORCID: 0000-0003-2945-3292
and Boateng, Joshua
ORCID: 0000-0002-6310-729X
(2010)
Freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa.
Journal of Pharmacy and Pharmacology, 62 (10).
pp. 1273-1274.
ISSN 0022-3573 (Print), 2042-7158 (Online)
(doi:https://doi.org/10.1111/j.2042-7158.2010.01178.x)
Abstract
The buccal mucosa has received increased attention in recent years for the delivery of proteins/peptides as an alternative to the currently used parenteral route [1]. Although limited by molecular size, hydrophobicity and low permeability of membranes, thiolated chitosan derivatives have however been identified to deliver proteins/peptides across the buccal mucosa because of their mucoadhesive, penetration enhancing and peptidase inhibition properties [2]. This project aims to develop freeze-dried thiolated chitosan formulations for protein delivery via the buccal mucosa and to determine the effectiveness of cryoprotection and annealing on the stability of the protein drug.
| Item Type: | Article |
|---|---|
| Additional Information: | [1] This is an abstract from a paper given at UK Pharmsci 2010 The Science of Medicines held at The East Midlands Conference Center, Nottingham, 1-3 September 2010. [2] This abstract is published in the Journal of Pharmacy and Pharmacology, Special Issue: UK-PharmSci 2010 - The Science of Medicines. Abstracts from the UK conference, 1-3 September, Volume 62, Issue 10, pages 1201–1516, October 2010. [3] First published online: 3 September 2010. |
| Uncontrolled Keywords: | chitosan, drug-delivery, mucoadhesive, freeze-drying, wafers, thiolated chitosan |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Faculty / School / Research Centre / Research Group: | Faculty of Engineering & Science > School of Science (SCI) |
| Related URLs: | |
| Last Modified: | 17 Oct 2016 09:10 |
| URI: | http://gala.gre.ac.uk/id/eprint/4151 |
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