Puente-Fernández, Joel, Larumbe-Zabala, Eneko, Jiménez, Alfonso, Liguori, Gary, Rossato, Claire ORCID: https://orcid.org/0000-0003-0306-5435, Mayo, Xian and Naclerio, Fernando ORCID: https://orcid.org/0000-0001-7405-4894 (2022) No impact of combining multi-ingredient supplementation with exercise on body composition and physical performance, in healthy middle-aged and older adults: a systematic review and meta-analysis. Experimental Gerontology, 172:112079. pp. 1-12. ISSN 0531-5565 (doi:10.1016/j.exger.2022.112079)

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Abstract

Background
Protein-based multi-ingredient (MTN) supplements have been suggested as a safe and effective way of enhancing exercise outcomes. However, their effectiveness remains controversial when compared to isocaloric and single-nutrient supplements. This review aims to systematically summarise the current knowledge of multi-ingredient supplementation to optimise body composition and physical performance in middle-aged and older adults.
Material and methods
A systematic review with meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search of the literature was conducted using PubMed, EBSCOhost, Google Scholar, Web of Science, and SPORTDiscus from June to October 2021. Every publication identified from the outset to October 2021 was considered. The main inclusion criteria comprised randomized controlled trial (RCT) studies conducted in adults (≥45 years old), following resistance- or endurance-based training programmes for a period of 6 weeks or longer, combined with MTN supplementation and a calorie equivalent comparator (COMP) supplement (e.g., carbohydrates). Continuous data on body composition [fat-free mass (FFM) or lean body mass], strength, and functional capacity as markers of physical performance were pooled using a random-effects model.
Results
Initially, 3329 publications were identified. Data from nine RCTs were ultimately included, involving 476 participants. The overall quality of the included studies was high, demonstrating a low risk of bias. Compared to COMP, no significant further benefits of ingesting MTN were identified for FFM (kg) (g = 0.044, 95 % CI −0.14 to 0.22), upper-body strength (kg) (g = 0.046, 95 % CI −0.24 to 0.33), lower-body strength, leg press exercise (kg) (g = 0.025, 95 % CI −0.26 to 0.31), leg extension exercise (kg) (g = 0.106, 95 % CI −0.15 to 0.36) and functional capacity (time in seconds) (g = 0.079, 95 % CI -0.12 to 0.27).
Conclusions
No additional benefits of ingesting MTN vs. COMP to maximise exercise-induced outcomes on body composition and physical performance in healthy physically active middle-aged and older adults have been identified.

Item Type:	Article
Uncontrolled Keywords:	multi-nutrient; supplement; lean mass; functional capacity; elderly
Subjects:	Q Science > Q Science (General) Q Science > QP Physiology R Medicine > RC Internal medicine > RC1200 Sports Medicine
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Chronic Illness and Ageing Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	09 Jan 2024 15:49
URI:	http://gala.gre.ac.uk/id/eprint/38370

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