Sanchez-Vazquez, Brenda, Lee, Jong Bong, Strimaite, Margarita, Buanz, Asma ORCID: 0000-0002-2556-1256 , Bailey, Russell, Gershkovich, Pavel, Pasparakis, George and Williams, Gareth R. (2019) Solid lipid nanoparticles self-assembled from spray dried microparticles. International Journal of Pharmaceutics, 572:118784. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2019.118784)

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Abstract

We report the self-assembly of drug-loaded solid lipid nanoparticles (SLNs) from spray dried microparticles comprising poly(vinylpyrrolidone) (PVP) loaded with glyceryl tristearate (GTS) and either indomethacin (IMC) or 5-fluorouracil (5-FU). When the spray dried microparticles are added to water, the PVP matrix dissolves and the GTS and drug self-assemble into SLNs. The SLNs provide a non-toxic delivery platform for both hydrophobic (IMC) and hydrophilic (5-FU) drugs. They show extended release profiles over more than 24 h, and in permeation studies the drug cargo is seen to accumulate inside cancer cells. This overcomes major issues with achieving local intestinal delivery of these active ingredients, in that IMC permeates well and thus will enter the systemic circulation and potentially lead to side effects, while 5-FU remains in the lumen of the small intestine and will be secreted without having any therapeutic benefit. The SLN formulations are as effective as the pure drugs in terms of their ability to induce cell death. Our approach represents a new and simple route to the fabrication of SLNs: by assembling these from spray-dried microparticles on demand, we can circumvent the low storage stability which plagues SLN formulations.

Item Type:	Article
Uncontrolled Keywords:	spray-drying, self-assembly, solid lipid nanoparticle, drug delivery system, stability
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	24 Aug 2022 11:52
URI:	http://gala.gre.ac.uk/id/eprint/37187

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