Khanna, Venkatesan Gopiesh, Kannabiran, Krishnan and Getti, Giulia ORCID: https://orcid.org/0000-0003-1402-8496 (2009) Leishmanicidal activity of saponins isolated from the leaves of Eclipta prostrata and Gymnema sylvestre. Indian Journal of Pharmacology, 41 (1). pp. 32-35. ISSN 0253-7613 (Print), 1998-3751 (Online) (doi:10.4103/0253-7613.48891)

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Abstract

Objective: To evaluate the leishmanicidal activity of saponin, dasyscyphin C of Eclipta prostrata and sapogenin, gymnemagenol from Gymnema sylvestre leaves under in vitro conditions.
Materials and Methods: Dasyscyphin C/Gymnemagenol were dissolved in phosphate buffered saline (PBS) and diluted with liquid medium to obtain concentrations ranging from 1000 to 15 µg /ml. The leishmanicidal activity against leishmanial parasites, Leishmania major, Leishmania aethiopica and Leishmania tropica promastigotes was studied by the MTS assay.
Result: The Dasyscyphin C isolated from E. prostrata showed good leishmanicidal activity at 1000µg/ml concentration, with the IC 50 value of 450µg/ml against L. major promastigote and the percentage of parasitic death was 73; whereas, gymnemagenol of G. sylvestre showed only 52% parasitic death at 1000 µg/ml concentration. The other Leishmania species, L. aethiopica and L. tropica promastigotes, were less sensitive to the saponins of E. prostrata and G. sylvestre.
Conclusion: From this study, it can be concluded that the dasyscyphin C of E. prostrata has significant leishmanicidal activity against L. major promastigote.

Item Type:	Article
Additional Information:	[1] This publisher gives immediate free access to the full text. [2] PMID: 20177579.
Uncontrolled Keywords:	Eclipta prostrata, Gymnema sylvestre, leishmania promastigotes, leishmanicidal activity, saponins
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	27 Jan 2020 12:09
URI:	http://gala.gre.ac.uk/id/eprint/3645

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