Kocurova, Gabriela, Ricny, Jan and Ovsepian, Saak (2022) Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases. Theranostics, 12 (7). pp. 3045-3056. ISSN 1838-7640 (Online) (doi:https://doi.org/10.7150/thno.72126)

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Abstract

Neurodegenerative diseases (NDDs) are associated with the accumulation of a range of misfolded proteins across the central nervous system and related autoimmune responses, including the generation of antibodies and the activation of immune cells. Both innate and adaptive immunity become mobilized, leading to cellular and humoral effects. The role of humoral immunity in disease onset and progression remains to be elucidated with rising evidence suggestive of positive (protection, repair) and negative (injury, toxicity) outcomes. In this study, we review advances in research of neuron-targeting autoantibodies in the most prevalent NDDs. We discuss their biological origin, molecular diversity and changes in the course of diseases, consider their relevance to the initiation and progression of pathology as well as diagnostic and prognostic significance. It is suggested that the emerging autoimmune aspects of NDDs not only could facilitate the early detection but also might help to elucidate previously unknown facets of pathobiology with relevance to the development of precision medicine.

Item Type:	Article
Uncontrolled Keywords:	fluid biomarkers, autoimmunity, dementia, differential diagnosis, immunoglobins
Subjects:	Q Science > QR Microbiology > QR180 Immunology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	11 Apr 2022 08:09
URI:	http://gala.gre.ac.uk/id/eprint/35638

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