Arribas-López, Elena, Zand Fard, Nazanin ORCID: 0000-0003-2058-2354, Ojo, Omorogieva ORCID: 0000-0003-0071-3652, Snowden, Martin ORCID: 0000-0002-1087-2692 and Kochhar, Tony (2022) A systematic review of the effect of Centella asiatica on wound healing. International Journal of Environmental Research and Public Health, 19 (6):3266. pp. 1-13. ISSN 1661-7827 (Online) (doi:https://doi.org/10.3390/ijerph19063266)

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Abstract

Background: Under metabolic stress conditions, there is a higher demand for nutrients which needs to be met. This is to reduce the risk of delay in wound healing which could lead to chronic wound. Aim: This is a systematic review of the effect of Centella asiatica on wound healing. C. asiatica is a traditional medicinal plant used due to its antimicrobial, antioxidant, anti-inflammatory, neuroprotective, and wound healing properties. Methods: PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed for the systematic review and four electronic databases were used. Results: Four clinical trials met the inclusion criteria. The following distinct areas were identified under C. asiatica: wound contraction and granulation; healing/bleeding time and re-epithelialization; VAS (visual analogue scale) scores; skin erythema and wound appearance. Conclusions: C. asiatica might enhance wound healing resulting from improved angiogenesis. This might occur due to its stimulating effect on collagen I, Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) production. Besides, C. asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and lipoxygenase (LOX) activity. Delivery systems such as nanoencapsulation could be used to increase C. asiatica bioavailability. Nevertheless, more studies are needed in order to perform a meta-analysis and ascertain the effects of C. asiatica on wound healing and its different parameters.

Item Type:	Article
Uncontrolled Keywords:	Centella asiatica; burn; cytokine; collagen; contraction; wound granulation; re-epithelialization; wound healing
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Chronic Illness and Ageing Faculty of Education, Health & Human Sciences > School of Health Sciences (HEA) Faculty of Engineering & Science > School of Science (SCI) Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Food & Markets Department
Last Modified:	05 May 2023 12:42
URI:	http://gala.gre.ac.uk/id/eprint/35473

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