Habtemariam, S. (2010) Knipholone anthrone from kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells. Fitoterapia, 81 (8). pp. 1013-1019. ISSN 0367-326X (doi:10.1016/j.fitote.2010.06.021)

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Abstract

The present study examines the comparative cytotoxicity of knipholone (KP) and knipholone anthrone (KA) in leukameic and melonocyte cancer cell lines. It was found that KA induces a rapid onset of cytotoxicity with IC50 values ranging from 0.5 - 3.3 mM. In comparison to KA, KP was 70-480-times less toxic to cancer cells. Morphological and biochemical studies revealed that the cytotoxicity of KA was coupled with a quick loss of membrane integrity leading to necrotic cell death. The study identified KA as a new class of natural potential anticancer agent with a wide range of toxicological and pharmacological implications.

Item Type:	Article
Uncontrolled Keywords:	Kniphofia foliosa (Asphodelaceae), Knipholone, Knipholone anthrone, cytotoxicity, apoptosis, necrosis
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	13 Dec 2019 11:59
URI:	http://gala.gre.ac.uk/id/eprint/3518

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