Jorratt, Pascal, Hoschl, Cyril and Ovsepian, Saak (2021) Endogenous antagonists of N-Methyl-D-Aspartate receptor in schizophrenia. Alzheimers and Dementia, 17 (5). pp. 888-905. ISSN 1552-5279 (Print), 1552-5279 (Online) (doi:10.1002/alz.12244)

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Abstract

Schizophrenia is a chronic neuropsychiatric brain disorder that has a devastating personal impact and rising healthcare costs. Dysregulation of glutamatergic neurotransmission has been implicated in the pathobiology of the disease, attributed largely to the hypofunction of the NMDA receptor. Currently, there is a major gap in the mechanistic analysis as to how endogenous modulators of the NMDA receptors contribute to the onset and progression of the disease. We present a systematic review of the neurobiology and the role of endogenous NMDA receptor antagonists in animal models of schizophrenia, and in patients. We discuss their neurochemical origin, release and action mechanisms, and functional effects, which could contribute to the impairments of neuronal processes underlying this complex pathological state. We consider clinical evidence suggesting dysregulations of endogenous NMDA receptors in schizophrenia, and highlight the pressing need in future studies and emerging directions, to restore the NMDA receptor functions for therapeutic benefits.

Item Type:	Article
Uncontrolled Keywords:	GluN1 subunit; autoimmune response; endocannabinoids; endogenous polyamines; kynurenic acid; neurosteroids; zinc
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Biology & Biotechnology Research Group Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	http://pubmed.ncbi.nlm.nih.gov/33336545/ Publisher
Last Modified:	11 Feb 2022 15:14
URI:	http://gala.gre.ac.uk/id/eprint/35164

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