Ahmed, Asif, Boateng, Joshua ORCID: 0000-0002-6310-729X and Getti, Giulia ORCID: 0000-0003-1402-8496 (2021) Medicated multi-targeted alginate-based dressings for potential treatment of mixed bacterial-fungal infections in diabetic foot ulcers. International Journal of Pharmaceutics, 606:120903. ISSN 0378-5173 (doi:https://doi.org/10.1016/j.ijpharm.2021.120903)

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Abstract

Recently developed medicated dressings target either bacterial or fungal infection only, which is not effective for the treatment of mixed infections common in diabetic foot ulcers (DFUs). This study aimed to develop advanced bioactive alginate-based dressings (films and wafers) to deliver therapeutically relevant doses of ciprofloxacin (CIP) and fluconazole (FLU) to target mixed bacterial and fungal infections in DFUs. The alginate compatibility with the drugs was confirmed by SEM, XRD, FTIR and texture analysis, while the medicated wafers showed better fluid handling properties than the films in the presence of simulated wound fluid. The dressings showed initial fast release of FLU followed by sustained release of CIP which completely eradicated E. coli, S. aureus, P. aeruginosa and reduced fungal load (C. albicans) by 10-fold within 24 h. Moreover, the medicated dressings were biocompatible (>70% cell viability over 72 h) with human primary adult keratinocytes and in-vitro scratch assay showed 65-68% wound closure within 7 days.

Item Type:	Article
Uncontrolled Keywords:	Calcium alginate, ciprofloxacin, diabetic foot ulcer, dressing, fluconazole, mixed infection
Subjects:	Q Science > Q Science (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	19 Jul 2022 01:38
URI:	http://gala.gre.ac.uk/id/eprint/33359

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