Lam, Kevin ORCID: 0000-0003-1481-9212 (2020) Kolbe anodic decarboxylation as a green way to access 2-pyrrolidinones. Organic Letters, 22 (5). pp. 1771-1775. ISSN 1523-7060 (doi:https://doi.org/10.1021/acs.orglett.0c00056)

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Abstract

Nootropic compounds are a group of pharmacologically active pyrrolidones. These molecules, which enhance cognition properties and possess a large prescription field, are particularly interesting synthetic targets for the pharmaceutical industry. In this Article, we disclose an effective and environmentally friendly pyrrolidinone synthesis using electrosynthesis. The newly developed methodology includes a Kolbe decarboxylation, followed by an intramolecular radical cyclization and a radical–radical cross-coupling.

Item Type:	Article
Uncontrolled Keywords:	Kolbe, nootropic, medchem, pharma
Subjects:	G Geography. Anthropology. Recreation > GE Environmental Sciences Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	13 Aug 2021 15:24
URI:	http://gala.gre.ac.uk/id/eprint/33249

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