Cooper, Ruth E. ORCID: https://orcid.org/0000-0002-9735-4731, Skirrow, Caroline, Tye, Charlotte, McLoughlin, Grainne, Rijsdijk, Fruhling, Banaschweski, Tobias, Brandeis, Daniel, Kuntsi, Jonna and Asherson, Philip (2014) The effect of methylphenidate on very low frequency electroencephalography oscillations in adult ADHD. Brain and Cognition, 86. pp. 82-89. ISSN 0278-2626 (doi:10.1016/j.bandc.2014.02.001)

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Abstract

Altered very low-frequency electroencephalographic (VLF-EEG) activity is an endophenotype of ADHD in children and adolescents. We investigated VLF-EEG case-control differences in adult samples and the effects of methylphenidate (MPH). A longitudinal case-control study was conducted examining the effects of MPH on VLF-EEG (.02–0.2 Hz) during a cued continuous performance task. 41 untreated adults with ADHD and 47 controls were assessed, and 21 cases followed up after MPH treatment, with a similar follow-up for 38 controls (mean follow-up = 9.4 months). Cases had enhanced frontal and parietal VLF-EEG and increased omission errors. In the whole sample, increased parietal VLF-EEG correlated with increased omission errors. After controlling for subthreshold comorbid symptoms, VLF-EEG case-control differences and treatment effects remained. Post-treatment, a time by group interaction emerged; VLF-EEG and omission errors reduced to the same level as controls, with decreased inattentive symptoms in cases. Reduced VLF-EEG following MPH treatment provides preliminary evidence that changes in VLF-EEG may relate to MPH treatment effects on ADHD symptoms; and that VLF-EEG may be an intermediate phenotype of ADHD. Further studies of the treatment effect of MPH in larger controlled studies are required to formally evaluate any causal link between MPH, VLF-EEG and ADHD symptoms.

Item Type:	Article
Uncontrolled Keywords:	attention deficit hyperactivity disorder (ADHD), electroencephalography (EEG), very low frequency oscillations (VLFOs), methylphenidate, default mode network, endophenotype
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	03 Jun 2021 10:32
URI:	http://gala.gre.ac.uk/id/eprint/32757

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