James, Amy M., Seal, Susan E. ORCID: https://orcid.org/0000-0002-3952-1562, Bailey, Andy M. ORCID: https://orcid.org/0000-0002-7594-3703 and Foster, Gary D. ORCID: https://orcid.org/0000-0002-1979-1397 (2021) Viral inosine triphosphatase: A mysterious enzyme with typical activity, but an atypical function. Molecular Plant Pathology, 22 (3). pp. 382-389. ISSN 1464-6722 (Print), 1364-3703 (Online) (doi:10.1111/mpp.13021)

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Abstract

Plant viruses typically have highly condensed genomes, yet the plant‐pathogenic viruses Cassava brown streak virus, Ugandan cassava brown streak virus, and Euphorbia ringspot virus are unusual in encoding an enzyme not yet found in any other virus, the “house‐cleaning” enzyme inosine triphosphatase. Inosine triphosphatases (ITPases) are highly conserved enzymes that occur in all kingdoms of life and perform a house‐cleaning function by hydrolysing the noncanonical nucleotide inosine triphosphate to inosine monophosphate. The ITPases encoded by cassava brown streak virus and Ugandan cassava brown streak virus have been characterized biochemically and are shown to have typical ITPase activity. However, their biological role in virus infection has yet to be elucidated. Here we review what is known of viral‐encoded ITPases and speculate on potential roles in infection with the aim of generating a greater understanding of cassava brown streak viruses, a group of the world's most devastating viruses.

Item Type:	Article
Additional Information:	© 2021 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords:	cassava brown streak disease, Euphorbia ringspot virus, ITPase
Subjects:	S Agriculture > S Agriculture (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department Faculty of Engineering & Science > Natural Resources Institute > Centre for Sustainable Agriculture 4 One Health Faculty of Engineering & Science > Natural Resources Institute > Centre for Sustainable Agriculture 4 One Health > Molecular Virology & Entomology
Last Modified:	27 Nov 2024 15:18
URI:	http://gala.gre.ac.uk/id/eprint/31843

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