Getti, G. T. M. ORCID: https://orcid.org/0000-0003-1402-8496, Aslam, S.N., Humber, D.P., Stevenson, P. C. ORCID: https://orcid.org/0000-0002-0736-3619 and Cheke, R. A. ORCID: https://orcid.org/0000-0002-7437-1934 (2006) The effect of Cicerfuran, an Arylbenzofuran from Cicer bijugum, and related Benzofurans and Stilbenes on Leishmania aethiopica, L. tropica and L. major. Planta Medica, 72 (10). pp. 907-911. ISSN 0032-0943 (doi:10.1055/s-2006-947187)

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Abstract

The effect of 3 arylbenzofurans and 7 stilbenes on the growth of Leishmania parasites and human monocytes was evaluated. Promastigotes from cultures of L. aethiopica, L. major and L. tropica were tested in the exponential phase of growth. All compounds were active at concentrations of 100 mu g/mL within 6 hours. The 2-hydroxylstibene showed activity at a concentration < 1 mu g/mL, with an LD50 of 3-5 mu g/mL after 48 hours of incubation. The most active compounds: cicerfuran, 2-hydroxy-2'-methyl4,5-methylenedioxystilbene, 2-hydroxy-2 -methoxy-4,5-methylenedioxystilbene and 2-hydroxystilbene had even stronger activity against the temperature-induced amastigotes of L. aethiopica, with the latter having the highest relative potency against all three species. Leishmanicidal activity seemed to be associated with the level of oxygen substitution in each compound. The ratio between leishmanicidal activity on promastigotes and toxicity to human cells suggested that the compounds could be considered as leishmanicidal drug leads.

Item Type:	Article
Uncontrolled Keywords:	Leishmania aethiopica, L. tropica, L. major, cicerfuran, benzofurans, THP-1 cells, antileishmanial activity
Subjects:	Q Science > Q Science (General) Q Science > QR Microbiology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Related URLs:	Publisher Organisation Organisation Organisation
Last Modified:	09 Oct 2021 04:46
URI:	http://gala.gre.ac.uk/id/eprint/3177

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