Marlow, Neil ORCID: 0000-0001-5890-2953, Ni, Yanyan, Lancaster, Rebecca, Suonpera, Emmi, Bernardi, Marialivia ORCID: 0000-0002-6844-0358, Fahy, Amanda, Larsen, Jennifer, Trickett, Jayne, Hurst, John R, Morris, Joan, Wolke, Dieter ORCID: 0000-0003-0304-268X and Johnson, Samantha (2021) No change in neurodevelopment at 11 years after extremely preterm birth. Archives of Disease in Childhood - Fetal and Neonatal Edition, 106 (4). pp. 418-424. ISSN 1359-2998 (Print), 1468-2052 (Online) (doi:https://doi.org/10.1136/archdischild-2020-320650)

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Abstract

Objective: To determine whether improvements in school age outcomes had occurred between two cohorts of births at 22 to 25 weeks of gestation to women resident in England in 1995 and 2006.

Design: Longitudinal national cohort studies.

Setting: School or home-based assessments at 11 years of age.

Participants: EPICure2 cohort of births at 22-26 weeks of gestation in England during 2006: a sample of 200 of 1031 survivors were evaluated; outcomes for 112 children born at 22-25 weeks’ gestation were compared to those of 176 born in England during 1995 from the EPICure cohort. Classroom controls for each group acted as a reference population.

Main outcome measures: Standardised measures of cognition and academic attainment were combined with parent report of other impairments to estimate overall neurodevelopmental status.

Results: At 11 years in EPICure2, 18% had severe and 20% moderate impairments. Comparing births at 22-25 weeks in EPICure2 (n=112), 26% had severe and 21% moderate impairment compared to 18% and 32% respectively in EPICure. After adjustment, the odds ratio of moderate or severe neurodevelopmental impairment in 2006 compared to 1995 was 0.76, 95%CI 0.45, 1.31; p=.32. IQ scores were similar in 1995 (mean 82.7; SD 18.4) and 2006 (81.4; SD 19.2), adjusted difference in mean z-scores 0.2SD (95%CI -0.2, 0.6), as were attainment test scores. The use of multiple imputation did not alter these findings.

Conclusion: Improvements in care and survival between 1995 and 2006 are not paralleled by improved cognitive or educational outcomes or a reduced rate of neurodevelopmental impairment.

Item Type:	Article
Uncontrolled Keywords:	extremely preterm birth
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	05 Jul 2022 12:58
URI:	http://gala.gre.ac.uk/id/eprint/31294

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