Emami, S. Noushin, Lindberg, Bo G., Hua, Susanna, Hill, Sharon R., Mozuraitis, Raimondas, Lehmann, Philipp, Birgersson, Göran, Borg-Karlson, Anna-Karin, Ignell, Rickard and Faye, Ingrid (2017) A key malaria metabolite modulates vector blood seeking, feeding, and susceptibility to infection. Science, 355 (6329). pp. 1076-1080. ISSN 0036-8075 (Print), 1095-9203 (Online) (doi:10.1126/science.aah4563)

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Abstract

Malaria infection renders humans more attractive to sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by , ()-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a -infected blood meal, sporogony is increased.

Item Type:	Article
Uncontrolled Keywords:	malaria and mosquitoes
Subjects:	S Agriculture > S Agriculture (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Agriculture, Health & Environment Department
Last Modified:	02 Feb 2021 13:21
URI:	http://gala.gre.ac.uk/id/eprint/30925

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