Hushmandi, Kiavash, Bokaie, Saied, Hashemi, Mehrdad, Moghadam, Ebrahim Rahmani, Raei, Mehdi, Hashemi, Farid, Bagheri, Mahdi, Habtemariam, Solomon and Nabavi, Seyed Mohammad (2020) A review of medications used to control and improve the signs and symptoms of COVID-19 patients. European Journal of Pharmacology, 887:173568. ISSN 0014-2999 (Print), 1879-0712 (Online) (doi:https://doi.org/10.1016/j.ejphar.2020.173568)

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Abstract

In December 2019, an unprecedented outbreak of pneumonia associated with a novel coronavirus disease 2019 (COVID-19) emerged in Wuhan City, Hubei province, China. The virus that caused the disease was officially named by the World Health Organization (WHO) as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). According to the high transmission rate of SARS-CoV-2, it became a global pandemic and public health emergency within few months. Since SARS-CoV-2 is genetically 80% homologous with the SARS-CoVs family, it is hypothesized that medications developed for the treatment of SARS-CoVs may be useful in the control and management of SARS-CoV-2. In this regard, some medication being tested in clinical trials and in vitro studies include anti-viral RNA polymerase inhibitors, HIV-protease inhibitors, anti-inflammatory agents, angiotensin converting enzyme type 2 (ACE 2) blockers, and some other novel medications. In this communication, we reviewed the general characteristics of medications, medical usage, mechanism of action, as well as SARS-CoV-2 related trials.

Item Type:	Article
Additional Information:	** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** History: accepted 14-09-2020; issue date 19-09-2020. ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
Uncontrolled Keywords:	novel corona virus; SARS-CoV-2; medications
Subjects:	Q Science > QR Microbiology > QR355 Virology R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
SWORD Depositor:	Publications Router
Last Modified:	05 Jun 2024 11:55
URI:	http://gala.gre.ac.uk/id/eprint/29718

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