Sahebnasagh, Adeleh, Saghafi, Fatemeh, Avan, Razieh, Khoshi, Amirhosein, Khataminia, Masoud, Safdari, Mohammadreza, Habtemariam, Solomon, Ghaleno, Hassan Rezai and Nabavi, Seyed Mohammad (2020) The prophylaxis and treatment potential of supplements for COVID-19. European Journal of Pharmacology, 887:173530. pp. 1-12. ISSN 0014-2999 (Print), 1879-0712 (Online) (doi:10.1016/j.ejphar.2020.173530)

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Abstract

The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months from the unprecedented socioeconomic disruption to more than 600,000 deaths. The lack of vaccine and effective therapeutic agents for the disease prompted world-wide effort to test those antiviral therapeutics already in use for other diseases. Another interesting approach has been based on the pathological sequel of the disease that involve severe inflammatory reaction (or the cytokine storm) associated with pneumonia in critically ill patients. This article outlines the prophylaxis therapeutic potential of supplements vitamins and micronutrients in COVID-19. By ameliorating the inflammatory and oxidative stress associated with the disease and some direct antiviral effects, the application of these agents as adjuvants and other alternative approaches are discussed. Available clinical trials including those currently registered on these supplements are scrutinized.

Item Type:	Article
Additional Information:	** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** History: accepted 28-08-2020; issue date 01-09-2020. ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
Uncontrolled Keywords:	COVID-19; coronavirus; supplements; vitamins; adjuvant therapy
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
SWORD Depositor:	Users 6393 not found.
Last Modified:	14 Jun 2024 10:00
URI:	http://gala.gre.ac.uk/id/eprint/29552

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