Dowran, Razieh, Nabavi, Seyed Fazel, Habtemariam, Solomon, Banach, Maciej, Shahmohamadnejad, Shiva, Cismaru, Cosmin Andrei, Berindan-Neagoe, Ioana, Sahebnasagh, Adeleh and Nabavi, Seyed Mohammad (2020) Various interferon (IFN)-inducible transmembrane (IFITM) proteins for COVID-19, is there a role for the combination of mycophenolic acid and interferon? Biochimie, 177. pp. 50-52. ISSN 0300-9084 (doi:10.1016/j.biochi.2020.08.006)

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Abstract

Various interferon (IFN)-inducible transmembrane (IFITM) proteins are known to be expressed in human tissues though only IFITM 1–3 are inducible by IFN. Numerous studies have shown that activation of IFITM3 could suppress infection by influenza and coronaviruses such as the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). In view of the potential application of IFITM proteins’ induction to target SARS-CoV-2 infection that causes COVID-19, this article layout insights into the known antiviral mechanisms and therapeutic agents related to IFITM. Blocking viral entry through various mechanisms and the potential application of the FDA approved immunosuppressant agent, mycophenolic acid, as inducer of IFITM3 are among those discussed.

Item Type:	Article
Additional Information:	** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** History: accepted 06-08-2020; issue date 14-08-2020. ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
Uncontrolled Keywords:	interferon (IFN)-inducible transmembrane (IFITM) protein; respiratory syndrome coronavirus (MERS-CoV);
Subjects:	Q Science > Q Science (General) Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
SWORD Depositor:	Users 6393 not found.
Last Modified:	07 Jun 2024 14:13
URI:	http://gala.gre.ac.uk/id/eprint/29216

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