Dominguez-Salas, Paula ORCID: 0000-0001-8753-4221, Moore, Sophie E., Baker, Maria S., Bergen, Andrew W., Cox, Sharon E., Dyer, Roger A., Fulford, Anthony J., Guan, Yongtao, Laritsky, Eleonora, Silver, Matt J., Swan, Gary E., Zeisel, Steven H., Innis, Sheila M., Waterland, Robert A., Prentice, Andrew M. and Hennig, Branwen J. (2014) Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications, 5 (1):3746. ISSN 2041-1723 (Online) (doi:https://doi.org/10.1038/ncomms4746)

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Abstract

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.

Item Type:	Article
Additional Information:	This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
Uncontrolled Keywords:	nutrition, epigenetics, seasonality, The Gambia
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Natural Resources Institute Faculty of Engineering & Science > Natural Resources Institute > Food & Markets Department
Last Modified:	31 Jul 2020 18:21
URI:	http://gala.gre.ac.uk/id/eprint/29119

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