McCrone, Paul ORCID: 0000-0001-7001-4502, Rost, Felicitas, Koeser, Leonardo, Koutoufa, Iakovina, Stephanou, Stephanie, Knapp, Martin, Goldberg, David, Taylor, David and Fonagy, Peter (2017) The economic cost of treatment-resistant depression in patients referred to a specialist service. Journal of Mental Health, 27 (6). pp. 567-573. ISSN 0963-8237 (Print), 1360-0567 (Online) (doi:https://doi.org/10.1080/09638237.2017.1417562)

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Abstract

Background: Patients with treatment-resistant depression (TRD) suffer very significant morbidity and are at a disadvantage concerning optimal clinical management. There are high associated societal costs.

Aims: A detailed analysis of health economic costs in the United Kingdom in a group manifesting a severe form of TRD in the 12 months before their participation in a major randomized controlled treatment trial.

Methods: The sample consisted of 118 participants from the Tavistock Adult Depression Study. Recruitment was from primary care on the basis of current major depression disorder of at least 2 years’ duration and two failed treatment attempts. Service utilization was assessed based on self-report and general practitioner (GP) medical records. Generalized linear models were used to identify predictors of cost.

Results: All participants used GP services. Use of other doctors and practice nurses was also high. The mean total societal cost was £22 124, 80% of which was due to lost work and care required of families. Level of general functioning was found to be the most consistent predictor of costs.

Conclusions: Severe forms of TRD are associated with high costs in which unpaid care and lost work predominate. Treatments that improve functioning may reduce the large degree of burden.

Item Type:	Article
Uncontrolled Keywords:	treatment-resistant depression, cost economic analysis, burden
Subjects:	H Social Sciences > HB Economic Theory R Medicine > R Medicine (General)
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development Faculty of Education, Health & Human Sciences > Institute for Lifecourse Development > Centre for Mental Health
Last Modified:	12 May 2020 08:23
URI:	http://gala.gre.ac.uk/id/eprint/27534

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