Jeandet, Philippe, Sobarzo-Sánchez, Eduardo, Silva, Ana Sanches, Clément, Christophe, Nabavi, Seyed Fazel, Battino, Maurizio ORCID: 0000-0002-7250-1782 , Rasekhian, Mahsa, Belwal, Tarun, Habtemariam, Solomon, Koffas, Mattheos ORCID: 0000-0002-1405-0565 and Nabavi, Seyed Mohammad (2019) Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives. Biotechnology Advances, 39:107461. ISSN 0734-9750 (Print), 1873-1899 (Online) (doi:https://doi.org/10.1016/j.biotechadv.2019.107461)

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Abstract

Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacological effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathway and their biological properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnology may provide a competitive approach for the large-scale and low cost production of biologically active stilbenes. Additionally, one major limitation in the use of resveratrol and related aglycone derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacologically resveratrol derivatives in vivo by exploiting whole microorganisms, enzymatic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biological activity through glucosylation (β-D-glucosides versus α-D-glucosides) and oligomerization methodologies of resveratrol including green chemistry methods in organic solvent-free medium are discussed as well.

Item Type:	Article
Additional Information:	** Article version: AM ** Embargo end date: 31-12-9999 ** From Elsevier via Jisc Publications Router ** History: accepted 15-10-2019; issue date 31-10-2019. ** Licence for AM version of this article: This article is under embargo with an end date yet to be finalised.
Uncontrolled Keywords:	biocatalytic; enzymatic; green chemistry methods; resveratrol; glucosylated derivatives
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry T Technology > TP Chemical technology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
SWORD Depositor:	Users 6393 not found.
Last Modified:	12 Jun 2024 14:52
URI:	http://gala.gre.ac.uk/id/eprint/25917

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