Leyva, Lida, Sirlin, Claude, Rubio, Laura, Franco, Cecilia, Le Lagadec, Ronan, Spencer, John, Bischoff, Pierre, Gaiddon, Christian, Loeffler, Jean-Philippe and Pfeffer, Michel (2007) Synthesis of cycloruthenated compounds as potential anticancer agents. European Journal of Inorganic Chemistry, 2007 (19). pp. 3055-3066. ISSN 1434-1948 (doi:https://doi.org/10.1002/ejic.200601149)

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Abstract

A library of 19 cycloruthenated derivatives is constructed by making use of the well-known cyclometalation reaction. Their geometries are modified in a straightforward manner by addition of either mono- or bidentate ligands, such as bipyridine, phenanthroline, 1,2-bis(diphenylphosphanyl)ethane, dimethylphenylphosphane, triphenylphosphane, and 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) ligands, to cationic cycloruthenated centers. The antitumor properties of the compounds thus obtained are investigated in order to compare them with recently reported ruthenium complexes and cisplatin. IC50 values against mammalian cells (A-172, HCT-116, and RDM-4) are determined for the library compounds and some of them, such as those derived from orthoruthenated phenylpyridine and a bidentate N,N ligand, display activity of the same order of magnitude as cisplatin.

Item Type:	Article
Uncontrolled Keywords:	bioinorganic chemistry, ruthenium, metallacycles, antitumor agents
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	13 Feb 2020 10:16
URI:	http://gala.gre.ac.uk/id/eprint/2512

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