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Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template

Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template

Spencer, John, Gaffen, John, Grifin, Eric, Harper, Elaine A., Linney, Ian D., McDonald, Iain M., Roberts, Sonia P., Shaxted, Mark E., Adatia, Trushar and Bashall, Alan (2008) Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template. Bioorganic & Medicinal Chemistry, 16 (6). pp. 2974-2983. ISSN 0968-0896 (doi:https://doi.org/10.1016/j.bmc.2007.12.047)

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Abstract

Novel, achiral 1H-1,3,5-benzotriazepine-2,4(3H,5H)-diones have been prepared and structurally characterized. These compounds are potent CCK2 receptor antagonists that display a high degree of selectivity over CCK1 receptors.

Item Type: Article
Additional Information: Erratum to "Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template" [Bioorg. Med. Chem. 16 (2008) 2974–2983] Bioorganic & Medicinal Chemistry, Volume 16, Issue 16, 15 August 2008, Page 7862. Adds John Spencer as corresponding author. No other errata.
Uncontrolled Keywords: CCK, CCK2, gastrin, antagonist, benzotriazepine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group: Faculty of Engineering & Science > School of Science (SCI)
Related URLs:
Last Modified: 11 Feb 2020 13:03
URI: http://gala.gre.ac.uk/id/eprint/2222

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