Nadarassan, D. K., Loni, A., Q. Shabir, Q., Kelly, C, O’Brien, H., Caffull, E., Webb, K., Canham, L. T., Maniruzamman, M, Trivedi, V. ORCID: https://orcid.org/0000-0001-9304-9214 and Douroumis, D. ORCID: https://orcid.org/0000-0002-3782-0091 (2015) Ultrahigh drug loading and release from biodegradable porous silicon aerocrystals. In: Controlled Release Society Meeting. CRS, pp. 42-43.

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Abstract

Biodegradable porous silicon (pSi) is under assessment for the controlled release of both proteins and poorly-soluble API formulations. Super-critical drying of ultrahigh porosity (90%) porous silicon is shown here to preserve much higher mesopore volumes (up to 4mL/g) and surface areas (up to 600m2M/g) than achievable with standardair drying. The payloads and physical state of the model drug (S) (+) ibuprofen, as loaded within a super-critically dried porous silicon carrier matrix,were quantified and assessed using TGA, DSC, cross-sectional EDX, XRD, Raman mapping andFT-IR. In-vitro biodegradability was assessed using Mmolybdenum blue assay and drug release using RPHPLC. Entrapped drug payloads as high as 70%w/w have been achieved, substantially higher than values reported for other mesoporous materials. The entrapped (S) (+) ibuprofen showed faster release than bulk (S) (+) ibuprofen.

Item Type:	Conference Proceedings
Title of Proceedings:	Controlled Release Society Meeting
Uncontrolled Keywords:	Ultrahigh Drug Loading, Biodegradable Porous Silicon, Aerocrystals, supercritical CO2
Subjects:	Q Science > QC Physics Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	19 May 2019 09:17
URI:	http://gala.gre.ac.uk/id/eprint/22162

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