Tetteh, J., Mader, K. T., Andanson, J.-M., McAuley, W.J., Lane, M.E., Hadgraft, J., Kazarian, S.G. and Mitchell, J. C. ORCID: 0000-0003-2945-3292 (2009) Local examination of skin diffusion using FTIR spectroscopic imaging and multivariate target factor analysis. Analytica Chimica Acta, 642 (1-2). pp. 246-256. ISSN 0003-2670 (doi:https://doi.org/10.1016/j.aca.2009.03.002)

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Abstract

In the context of trans-dermal drug delivery it is very important to have mechanistic insight into the barrier function of the skin's stratum corneum and the diffusion mechanisms of topically applied drugs. Currently spectroscopic imaging techniques are evolving which enable a spatial examination of various types of samples in a dynamic way. ATR-FTIR imaging opens up the possibility to monitor spatial diffusion profiles across the stratum corneum of a skin sample. Multivariate data analyses methods based on factor analysis are able to provide insight into the large amount of spectroscopically complex and highly overlapping signals generated. Multivariate target factor analysis was used for spectral resolution and local diffusion profiles with time through stratum corneum. A model drug, 4-cyanophenol in polyethylene glycol 600 and water was studied. Results indicate that the average diffusion profiles between spatially different locations show similar profiles despite the heterogeneous nature of the biological sample and the challenging experimental set-up.

Item Type:	Article
Additional Information:	[1] Available online: 17 March 2009. [2] Published in print: 29 May 2009. [3] Published in Analytica Chimica Acta (2009), Volume 642, Issues 1–2, pp. 246–256. [4] This paper was originally presented at the 11th International Conference on Chemometrics in Analytical Chemistry — CAC 2008 in Montpellier, France.
Uncontrolled Keywords:	Fourier transform infrared spectroscopy, skin, stratum corneum, target factor analysis, Fourier transform infrared imaging
Subjects:	R Medicine > RS Pharmacy and materia medica Q Science > QM Human anatomy
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	07 Feb 2020 13:29
URI:	http://gala.gre.ac.uk/id/eprint/2069

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