Hevesi Tóth, Barbara, Houghton, P.J., Habtemariam, Solomon and Kéry, Á. (2009) Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb. Phytotherapy Research, 23 (5). pp. 719-724. ISSN 0951418X (doi:10.1002/ptr.2725)

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Abstract

Epilobium parviflorum Schreb. (Onagraceae) is used for the treatment of benign prostatic hyperplasia (BPH), but its biological action is not entirely identified. This paper aims to report data on E. parviflorum with respect to its antioxidant and antiinflammatory effects. The aqueous acetone extract of E. parviflorum showed higher antioxidant effect in the DPPH assay than well known antioxidants and inhibited the lipid peroxidation determined by the TBA assay (IC(50) = 2.37 +/- 0.12 mg/mL). In concentrations of 0.2-15.0 microg/mL the extract possessed a protective effect, comparable to catalase (250 IU/mL), against oxidative damage, generated in fibroblast cells. In the COX inhibition assay E. parviflorum decreased the PGE(2) release, so showing inhibition of the COX-enzyme (IC(50) = 1.4 +/- 0.1 microg/mL).

Item Type:	Article
Additional Information:	[1] Published online 23 December 2008.
Uncontrolled Keywords:	Epilobium parviflorum, BPH, DPPH, TBA, fibroblast, COX-enzyme
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation Organisation
Last Modified:	07 Feb 2020 12:31
URI:	http://gala.gre.ac.uk/id/eprint/2059

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