Li, Dian-Jeng, Tseng, Ping-Tao, Stubbs, Brendon, Chen, Tien-Yu, Lin, Pao-Yen, Chen, Shiou-Lan, Thompson, Trevor ORCID: 0000-0001-9880-782X , Adamis, Dimitrios and Chu, Che-Sheng (2018) Low peripheral levels of insulin growth factor-1 are associated with high incidence of delirium among elderly patients: A systematic review and meta-analysis. Archives of Gerontology and Geriatrics, 77. ISSN 0167-4943 (Print), 1872-6976 (Online) (doi:https://doi.org/10.1016/j.archger.2018.03.011)

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Abstract

Introduction:

Delirium, a serious condition observed in critically ill patients, clinically presents with impaired cognition and consciousness. The relationship between delirium and peripheral levels of insulin growth factor-1 (IGF-1) is unclear. Thus we conducted a meta-analysis to address this issue.

Methods:

Seven major electronic databases were searched from inception until October 2, 2017 to obtain relevant clinical variables to compare the difference in IGF-1 levels between delirious and non-delirious elderly in-patients. A random effects meta-analysis was conducted.

Results:

We studies 10 articles involving 294 delirious patients (mean age 73.0 years) and 604 non-delirious patients (mean age 76.9 years). We found that peripheral levels of IGF-1 in patients with delirium were significantly lower than in those without delirium (Hedges‘ g = −0.209, 95% confidence interval [CI] = −0.393 to −0.026, p = 0.025). Meta-regression analyses found that no variables such as percentage of cognitive impairment, mean age, and female proportion contribute to heterogeneity in terms of the entire population.

Conclusions:

Our data suggests that lower peripheral levels of IGF-1 could be associated with a higher incidence of delirium among elderly patients. Further prospective studies with larger sample sizes are needed to investigate the association between peripheral levels of IGF-1 and delirium.

Item Type:	Article
Uncontrolled Keywords:	Biomarker; Delirium; Elderly; IGF-1; Meta-analysis
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	20 Mar 2019 01:38
URI:	http://gala.gre.ac.uk/id/eprint/19581

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