Veronese, Nicola, Koyanagi, Ai, Stubbs, Brendon, Solmi, Marco, Fornaro, Michele, Fernandes, Brisa S., Muller, Christoph, Thompson, Trevor ORCID: https://orcid.org/0000-0001-9880-782X, Carvalho, André F. and Maggi, Stefania (2017) Aspirin and incident depressive symptoms: A longitudinal cohort study over 8 years. International Journal of Geriatric Psychiatry, 33 (2). e193-e198. ISSN 0885-6230 (Print), 1099-1166 (Online) (doi:10.1002/gps.4767)

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Abstract

OBJECTIVE:
Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort. METHODS: Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed. Aspirin use was defined through self-report in the past 30 days and confirmed by a trained interviewer. Incident depressive symptoms were defined as a score of ≥16 in the 20-item Center for Epidemiologic Studies-Depression scale.

RESULTS:
A total of 137 participants (mean age 65 y, 55.5% female) were using aspirin at baseline. Compared with 4003 participants not taking aspirin, no differences in Center for Epidemiologic Studies-Depression at baseline were evident (P = .65). After a median follow-up time of 8 years, the incidence of depressive symptoms was similar in those taking aspirin at baseline (43; 95% CI, 3-60) and in aspirin nonusers (38; 95% CI, 36-41) per 1000 y; log-rank test = 0.63). Based on Cox's regression analysis adjusted for 11 potential confounders, aspirin use was not significantly associated with the development of depressive symptoms (hazard ratio = 1.12; 95% CI, 0.78-1.62; P = .54). Adjustment for propensity scores or the use of propensity score matching did not alter the results.

CONCLUSION:
Our study found that prescription of aspirin offered no significant protection against incident depressive symptoms. Whether aspirin is beneficial in a subgroup of depression with high levels of inflammation remains to be investigated in future studies.

Item Type:	Article
Uncontrolled Keywords:	aspirin; cohort; depression; epidemiology; psychiatry; survey
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	15 Feb 2018 15:12
URI:	http://gala.gre.ac.uk/id/eprint/19241

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