Scoutaris, Nikolaos, Ross, Steven A. and Douroumis, Dennis ORCID: https://orcid.org/0000-0002-3782-0091 (2018) 3D printed "Starmix" drug loaded dosage forms for paediatric applications. Pharmaceutical Research, 35. ISSN 0724-8741 (Print), 1573-904X (Online) (doi:10.1007/s11095-017-2284-2)

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Abstract

Purpose:
Three- dimensional (3D) printing has received significant attention as a manufacturing process for pharmaceutical dosage forms. In this study, we used Fusion Deposition Modelling (FDM) in order to print "candy - like" formulations by imitating Starmix sweets to prepare paediatric medicines with enhanced palatability. Methods Hot melt extrusion processing (HME) was coupled with FDM to prepare extruded filaments of indomethacin (IND), hypromellose acetate succinate (HPMCAS) and polyethylene glycol (PEG) formulations and subsequently feed them in the 3D printer. The shapes of the Starmix objects were printed in the form of a heart, ring, bottle, ring, bear and lion. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Fourier Transform Infra-red Spectroscopy (FT-IR) and confocal Raman analysis were used to assess the drug - excipient interactions and the content uniformity.

Results:
Physicochemical analysis showed the presence of molecularly dispersed IND in the printed tablets. In vivo taste masking evaluation demonstrated excellent masking of the drug bitterness. The printed forms were evaluated for drug dissolution and showed immediate IND release independently of the printed shape, within 60min.

Conclusions:
3D printing was used successfully to process drug loaded filaments for the development of paediatric printed tablets in the form of Starmix designs.

Item Type:	Article
Uncontrolled Keywords:	3D printing, Paediatric medicines, Fusion deposition modelling, Hot melt extrusion, Taste masking
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Centre for Innovation and Process Engineering in Research (CIPER) Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher
Last Modified:	19 May 2019 09:17
URI:	http://gala.gre.ac.uk/id/eprint/18174

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