Hooper, D., Clarke, F. C., Docherty, R., Mitchell, J. C. ORCID: https://orcid.org/0000-0003-2945-3292 and Snowden, M. J. ORCID: https://orcid.org/0000-0002-1087-2692 (2017) Effects of crystal habit on the sticking propensity of ibuprofen — A case study. International Journal of Pharmaceutics, 531 (1). pp. 266-275. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2017.08.091)

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Abstract

This study demonstrates the effect of active pharmaceutical ingredient (API) particle habit on the sticking propensity of ibuprofen. Four diverse crystal habits with similar physico chemical properties are reported and the sticking propensity was found to increase with shape regularity. The surface energy of the extreme habits were shown to be different where particles that were more regular in shape exhibited surface energies of 9 mJ/m2 higher than those that were needle-like in habit. Computational and experimental data reveals that the increase in surface energy of the regular shaped particles can be attributed to the increase in the specific (polar) component, which is due to greater presence of faces which contain the carboxylic acid functionality at the surface. The increase in the specific energy component is shown to correlate with the sticking propensity of ibuprofen. It is proposed that investigation of the chemical causality of sticking, for this API and others, using the techniques demonstrated in this paper will be of increasing importance

Item Type:	Article
Uncontrolled Keywords:	Particle shape; Surface energy; Punch sticking; Crystal chemistry
Subjects:	Q Science > QD Chemistry
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	16 Apr 2020 13:26
URI:	http://gala.gre.ac.uk/id/eprint/17581

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