Waters, Laura J., Finch, Catherine V., Bhuiyan, A.K.M. Mehedi H., Hemming, Karl and Mitchell, John C. ORCID: 0000-0003-2945-3292 (2017) Effect of plasma surface treatment of poly (dimethylsiloxane) on the permeation of pharmaceutical compounds. Journal of Pharmaceutical Analysis, 7 (5). pp. 338-342. ISSN 2095-1779 (doi:https://doi.org/10.1016/j.jpha.2017.05.003)

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Abstract

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS both with, and without, plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds yet had little effect for some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values implying plasma-modified silicone membrane (PMSM) could be considered a suitable in vivo replacement to predict clinical skin permeation

Item Type:	Article
Additional Information:	Open Access funded by Xi'an Jiaotong University
Uncontrolled Keywords:	Permeation; PDMS; Silicone; Plasma; Flux; Hydrophobicity
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > Medway Centre for Pharmaceutical Science Faculty of Engineering & Science > Medway Centre for Pharmaceutical Science > Pharmaceutical and Medicinal Science Research Group
Last Modified:	07 Nov 2017 12:51
URI:	http://gala.gre.ac.uk/id/eprint/17341

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