University of Greenwich (2016) Triazine derivatives as interferon gamma inhibitors. WO 2016/109978 A1.

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Abstract

The present invention relates to interferon-gamma (IFN-γ) inhibitors, and their utility in treating or controlling diseases that can be treated or controlled through inhibition of IFN-γ production, such as Alzheimer's disease, prion diseases, multiple sclerosis, epilepsy, rheumatoid arthritis, inflammatory bowel disease, uveitis, autoimmune skin diseases, psoriasis, Sjögren's syndrome, Crohn's disease, and type 1 diabetes mellitus. The compounds are of Formula 1, 2 3, or are solvates, tautomers, or pharmaceutically acceptable salts thereof; (I), (II), (III) in which: A is an aromatic ring selected from; i. a phenyl ring substituted with up to five substituents, each independently selected from halogen atoms, haloalkyl groups having from 1 to 4 carbon atoms, alkoxy groups having from 1 to 4 carbon atoms, and haloalkoxy groups having from 1 to 4 carbon atoms; ii. a thiophene ring optionally substituted with up to three substituents each selected independently from halogen atoms, alkyl groups having from 1 to 4 carbon atoms, haloalkyl groups having from 1 to 4 carbon atoms, alkoxy groups having from 1 to 4 carbon atoms and haloalkoxy groups having from 1 to 4 carbon atoms; and iii. a C(Rd)3 group, wherein each Rd is independently selected from hydrogen, alkyl groups having from 1 to 4 carbon atoms, haloalkyl groups having from 1 to 4 carbon atoms, alkoxy groups having from 1 to 4 carbon atoms, haloalkoxy groups having from 1 to 4 carbon atoms, and phenyl rings optionally substituted with up to five substituents, each independently selected from halogen atoms, alkyl groups having from 1 to 4 carbon atoms, haloalkyl groups having from 1 to 4 carbon atoms, alkoxy groups having from 1 to 4 carbon atoms, and haloalkoxy groups having from 1 to 4 carbon atoms, cycloalkyl groups having from 3 to 8 carbon atoms, halocycloalkyl groups having from 3 to 8 carbon atoms, and wherein at least one Rd is an optionally substituted phenyl ring; Ra is selected from hydrogen, haloalkyl groups having from 1 to 4 carbon atoms, and alkyl-alkoxy groups having from 1 to 6 carbon atoms that are optionally substituted with one or more halogen atoms, with the proviso that when A is a phenyl ring comprising one or more directly bound halogen substituents, the compound is of Formula 2 or Formula 3, and Ra is not hydrogen; and each Rb is independently selected from hydrogen, and alkyl groups having from 1 to 4 carbon atoms, and haloalkyl groups having from 1 to 4 carbon atoms.

Item Type:	Patent
Uncontrolled Keywords:	Cytokines; Interferon gamma; Triazines
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	09 Oct 2021 04:45
URI:	http://gala.gre.ac.uk/id/eprint/16252

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