Owusu-Ware, Samuel K., Chowdhry, Babur Z., Leharne, Stephen A. and Antonijevic, Milan D. ORCID: https://orcid.org/0000-0002-5847-7886 (2016) Phase behaviour of dehydrated phosphatidylcholines. Journal of Thermal Analysis and Calorimetry, 127 (1). pp. 415-421. ISSN 1388-6150 (Print), 1572-8943 (Online) (doi:10.1007/s10973-016-5957-x)

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Abstract

Dehydrated DLPC, DMPC, DPPC and DSPC have been characterised at temperatures below the diacyl carbon chain-melting transition (Tm), using DSC. For the first time, the existence of pre-Tm transition processes, which are, usually, only observed in the colloidal/liposomal state of saturated phospholipids have been detected for the dehydrated phosphatidylcholines. Temperature modulated differential scanning calorimetry (TMDSC) was used to characterize the several complex, overlapping pre-Tm transition processes. Kinetic studies of the chain-melting (Tm) transition show the activation energy dependence on α (conversion rate) i.e. activation energy decreases as the transition progresses, pointing to the importance of initial cooperative (intra- and inter-molecular) mobility. Furthermore the activation energy increases with increase in diacyl chain length of the phosphatidylcholines which supports the finding that greater molecular interactions of the polymer chain and its head groups in the dehydrated solid state lead to enhanced stability of dehydrated phosphatidylcholines.

Item Type:	Article
Uncontrolled Keywords:	Phospholipids; Dehydrated phosphatidylcholines; Differential scanning calorimetry; Phase transitions
Subjects:	T Technology > TA Engineering (General). Civil engineering (General)
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	02 May 2020 12:03
URI:	http://gala.gre.ac.uk/id/eprint/16000

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