Coleman, Nichola J., Bishop, Alistair H., Booth, Samantha E. and Nicholson, John W. (2008) Ag+- and Zn2+-exchange kinetics and antimicrobial properties of 11 angstrom tobermorites. Journal of the European Ceramic Society, 29 (6). pp. 1109-1117. ISSN 0955-2219 (doi:https://doi.org/10.1016/j.jeurceramsoc.2008.08.015)

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Abstract

Ag+- and Zn2+-exchanged zeolites zeolites and clays have been used as coatings and in composites to confer broad-spectrum antimicrobial properties on a range of technical and biomedical materials. 11 angstrom tobermorite is a bioactive layer lattice ion exchanger whose potential as a carrier for Ag+ and Zn2+ ions in antimicrobial formulations has not yet been explored. In view of this, batch Ag+- and Zn2+-exchange kinetics of two structurally distinct synthetic 11 angstrom tobermorites and their subsequent bactericidal action against Staphylococcus aureus and Pseudomonas aeruginosa are reported. During the exchange reactions, Ag+ ions were found to replace labile interlayer cations; whereas, Zn2+ ions also displaced structural Ca2+ ions from the tobermorite lattice. In spite of these different mechanisms, a simple pseudo-second-order model provided a suitable description of both exchange processes (R-2 >= 0.996). The Ag+- and Zn2+-exchanged tobermorite phases exhibited marked bacteriostatic effects against both bacteria, and accordingly, their potential for use as antimicrobial materials for in situ bone tissue regeneration is discussed. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type:	Article
Additional Information:	[1] Available online 24 September 2008; published in print: April 2009.
Uncontrolled Keywords:	chemical properties, biomedical applications, silicate, pseudo-second-order kinetics
Subjects:	T Technology > TP Chemical technology R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation
Last Modified:	10 Feb 2020 13:15
URI:	http://gala.gre.ac.uk/id/eprint/1565

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