Coleman, Nichola J. (2009) Aspects of the in vitro bioactivity and antimicrobial properties of Ag+- and Zn2+-exchanged 11 Å tobermorites. Journal of Materials Science: Materials in Medicine, 20 (6). pp. 1347-1355. ISSN 0957-4530 (Print), 1573-4838 (Online) (doi:https://doi.org/10.1007/s10856-009-3698-0)

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Abstract

11 Å tobermorite, Ca5Si6O16(OH)2 · 4H2O, is a layer lattice ion exchange mineral whose potential as a carrier for Ag+ and Zn2+ ions in antimicrobial, bioactive formulations has not yet been explored. In view of this, the in vitro bioactivity of Ag+- and Zn2+-exchanged 11 Å tobermorites and their bactericidal action against S. aureus and P.aeruginosa are reported. The in vitro bioactivity of the synthetic unsubstituted tobermorite phase was confirmed by the formation of bone-like hydroxycarbonate apatite (HCA) on its surface within 48 h of contact with simulated body fluid. The substitution of labile Ag+ ions into the tobermorite lattice delayed the onset of HCA-formation to 72 h; whereas, the Zn2+-substituted phase failed to elicit an HCA-layer within 14 days. Both Ag+- and Zn2+-exchanged tobermorite phases were found to exhibit marked antimicrobial action against S. aureus and P.aeruginosa, two common pathogens in biomaterial-centred infections.

Item Type:	Article
Additional Information:	[1] The original publication is available at www.springerlink.com. [2] The Journal of Materials Science: Materials in Medicine is the official journal of the European Society for Biomaterials (ESB).
Uncontrolled Keywords:	bone formation, ion-exchange, zinc, silver
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation Organisation
Last Modified:	17 Oct 2016 09:09
URI:	http://gala.gre.ac.uk/id/eprint/1561

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