Boyapally, Harikrishna, Nukala, Ravi Kumar and Douroumis, Dionysios ORCID: 0000-0002-3782-0091 (2009) Development and release mechanism of diltiazem HCl prolonged release matrix tablets. Drug Delivery, 16 (2). pp. 67-74. ISSN 1071-7544 (doi:https://doi.org/10.1080/10717540802586220)

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Abstract

A coated matrix tablet formulation has been used to develop controlled release diltiazem HCl (DIL) tablets. The developed drug delivery system provided prolonged drug release rates over a defined period of time. DIL tablets prepared using dry mixing and direct compression and the core consisted of hydrophilic and hydrophobic polymers such as hydroxypropylmethylcellulose (HPMC), Eudragits RLPO/RSPO, microcrystalline cellulose, and lactose. Tablets were coated with Eudragit NE 30D, and the influence of varying the inert hydrophobic polymers and the amount of the coating polymer were investigated. The release profile of the developed formulation was described by the Higuchi model. Stability trials up to 6 months displayed excellent reproducibility.

Item Type:	Article
Uncontrolled Keywords:	matrix tablets, direct compression, sustained release, higuchi model, diltiazem hydrochloride, drug stability, tablets
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science > School of Science (SCI)
Related URLs:	Publisher Organisation Organisation
Last Modified:	07 Feb 2020 15:30
URI:	http://gala.gre.ac.uk/id/eprint/1551

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