Richardson, Dyer, Mitchell (2014) WO 2014203008 A1 Antisense oligonucleotide compositions. WO2014203008 A1.

	PDF (Patent Application) WO2014203008_ANTISENSE_OLIGONUCLEOTIDE_COMPOSITIONS.pdf - Published Version Restricted to Registered users only Download (1MB)
	PDF (Extended Abstract) 14905_MITCHELL_WO_2014203008_A1_2014.pdf - Draft Version Restricted to Registered users only Download (250kB)

Abstract

The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridising to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.

Item Type:	Patent
Uncontrolled Keywords:	antisense oligonucleotide; ASO; cytosolic delivery
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI) Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	09 Oct 2021 04:46
URI:	http://gala.gre.ac.uk/id/eprint/14905

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