Adebisi, Adeola, Kaialy, Waseem, Hussain, Tariq, Hamidi, Hiba, Nokhodchi, Ali, Conway, Barbara and Addo, Kofi (2016) An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine. Powder Technology, 292. pp. 342-350. ISSN 0032-5910 (Print), 1873-328X (Online) (doi:https://doi.org/10.1016/j.powtec.2016.02.008)

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Abstract

One of strategies adopted to improve the dissolution rates of poorly soluble drugs is by co-grinding the drug with a hydrophilic carrier. However, the introduction of mechanical forces during the grinding process can lead to changes in the physicochemical characteristics as well as an increase in the surface free energy of the ground particles, which causes an alteration in the electrostatic properties of these particles. The solid state characteristics of glucosamine hydrochloride (GLU) and carbamazepine (CBZ) and their co-ground mixtures were studied using DSC, XRPD and SEM. These revealed that polymorphic transformations occurred due to the grinding process. The influence of grinding time on the triboelectrification properties of the formulations was also studied. Both pure CBZ and GLU powders were predominantly electro-positively charged and their charging properties increased with increasing grinding time. CBZ:GLU physical mixtures exhibited complicated bipolar charging behaviour, however, when subjected to grinding, these mixtures demonstrated mainly electronegative charge properties. The influence of both grinding time and CBZ content within CBZ:GLU mixtures were examined. The value of net-electronegative-charge density of CBZ:GLU mixtures was shown to increase with grinding time and /or when increasing the percentage proportion of CBZ up to 30% w:w. This study helps to provide information about the handling of these formulation and gives a formulator tools to ascertain appropriate ratios for handling and possible simultaneous dissolution improvements.

The novel technique reported here for determining the charge of the dispersions could therefore also be used as tool to help a formulator determine the appropriate formulations that enhance dissolution but also improve handling.

Item Type:	Article
Additional Information:	"This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Uncontrolled Keywords:	Electrostatic, Solid dispersion, Triboelectrification, Carbamazepine, D-glucoseamine HCL; Polymorphisim
Faculty / School / Research Centre / Research Group:	Faculty of Engineering & Science Faculty of Engineering & Science > School of Science (SCI)
Last Modified:	07 Feb 2018 01:38
URI:	http://gala.gre.ac.uk/id/eprint/14569

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