Rahman, Aziz M., Hwang, Gyulin, Müller, Ferenc, Williams, Darren W., Murdock, Paul J., Pasi, K. John, Goldspink, Geoffrey, Farahmand, Hamid and Maclean, Norman (2004) Fish as bioreactors: Transgene expression of human coagulation factor VII in fish embryos. Marine Biotechnology, 6 (5). pp. 485-492. ISSN 1436-2228 (Print), 1436-2236 (Online) (doi:https://doi.org/10.1007/s10126-004-3121-2)

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Abstract

A plasmid containing human coagulation factor VII (hFVII) complementary DNA regulated by a cytomegalovirus promoter was microinjected into fertilized eggs of zebrafish, African catfish, and tilapia. The active form of hFVll was detected in the fish embryos by various assays. This positive expression of human therapeutic protein in fish embryos demonstrates the possibility of exploitation of transgenic fish as bioreactors.

Item Type:	Article
Uncontrolled Keywords:	human coagulation factor VII, transgenic fish, bioreactor.
Faculty / School / Research Centre / Research Group:	Faculty of Education, Health & Human Sciences > School of Human Sciences (HUM)
Last Modified:	09 Oct 2021 04:46
URI:	http://gala.gre.ac.uk/id/eprint/14498

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